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Country Discussion Topics
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A few words on DNA science
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Clod    Posted 06-17-2004 at 10:54:08       [Reply]  [No Email]
>The environment surrounding DNA in living cells plays a surprisingly important role in regulating the movement of electronic charge through the life-coding molecule, suggests a paper published October 19 in the journal Science. The work could lead to a better understanding of how DNA is damaged by oxidative processes and offer clues to potential DNA applications in nanotechnology.

Based on experimental data, computer-based molecular dynamics simulations and complex electronic structure calculations, the paper is the first to describe how sodium ions could control the migration of electron holes -- also known as radical cations -- through DNA. The electron holes, positively charged locations in the DNA structure, are created by normal cellular oxidation processes and everyday events such as exposure to sunlight. Migrating through the DNA to distances up to 30 nanometers from their site of origin, the electron holes ultimately reach certain locations where they may initiate reactions that can damage the genetic coding.


Uzi Landman (left) and Gary Schuster compare results of a molecular dynamics simulation to experimental data. A paper published in the October 19 issue of Science suggests the environment surrounding DNA plays a key role in controlling charge transport.

Photo by Gary Meek (300-dpi JPEG version - 407K)

"Our paper presents a new way of thinking about what controls electrical charge transport in DNA," said Gary Schuster, a professor in the School of Chemistry and Biochemistry at the Georgia Institute of Technology and dean of its College of Sciences. "It is the motions of the water molecules, the sodium ions, the backbone of the DNA and the bases of the DNA that altogether control the movement of charge in the DNA. It's clear that we must consider both the DNA and its environment."

Underlying the charge migration mechanism unveiled in this study are two physical principles: (1) like electrical charges electrostatically repel one another, and (2) thermal energy induces random motion -- known as stochastic dynamic fluctuations -- among the microscopic constituents of matter: ions, atoms and molecules.

In a 1999 paper published in Proceedings of the National Academy of Sciences, Schuster and his colleagues suggested that electrical charge moves through DNA in a "Slinky-like" process in which the molecule distorts itself in an effort to locally stabilize the charge. The new work seeks to explain why the charge moves at all, and to elucidate the dynamical mechanism of long-range transport in DNA.

In a nutshell, the paper's authors argue that the positively charged electron holes -- created by the removal of an electron -- move when approached by positively charged sodium ions hydrated in the aqueous medium surrounding the DNA. Circulated by thermal energy in a random way, the diffusing sodium ions are attracted to specific locations in the DNA, such as the negatively charged
>


Grove r    Posted 06-17-2004 at 12:17:44       [Reply]  [No Email]
Nanotechnology is the new frontier, coupled with biotecnology, can be concieved as taking this another step further....possibiltys are limitless, can you imagine a prosthesis that is controled by the nerves that used to contole the REAL appendage??? this gets to the point of being a bit scarry....R.E.L.


Burrhead    Posted 06-17-2004 at 12:46:01       [Reply]  [No Email]
DNA is alright but we all know *if the glove don't fit, we must aquit*


Bob/Ont    Posted 06-17-2004 at 11:27:40       [Reply]  [No Email]
Clod you are sounding more like a scientist every day.
Later Bob


Clod    Posted 06-17-2004 at 10:58:17       [Reply]  [No Email]
This reminds me a of a song."Now if that aint country." But country folks get into discussions of things like DNA and blackhole theory..Somewhere else accoding to my un named source.


Jimbob    Posted 06-17-2004 at 11:12:59       [Reply]  [No Email]
A bit (lot) beyond me. However, I wish more research be performed on the bodies time clock encoded in DNA to extend life and continue the bodies repair at 100% capacity.

The only cells that can not divide & renew is the brain (trashes memory & other functions). With 900+ years of brain cells, it is not an issue. Imagine living 900 years and what a modest CD invested would be worth after 150 years. The old saying would be more true than ever- 'time is on your side'.


Patria    Posted 06-17-2004 at 11:08:13       [Reply]  [No Email]
Did your source gave you directions? or draw you a map of such a niche...? :-)


Clod    Posted 06-17-2004 at 16:20:59       [Reply]  [No Email]
I have my own theory of personallity.Each and every humand can be idetified by traits in their personality .No matter which name they use or if they try to decieve persons with an act you can find the real person behind the mask of deception. I know I could not play false here with Lenore because she knows me well.So I never make up a name to hide my identity to lodge a complaint about the intelligence of posters on this board. Besides..I like the most of the post here anyhow.If I wanted to post with interlectials I could easily find some doing what they do best.Pretending to be smarter than the avearage bear.Even Shakespeare didnt pretend to be intelligent.He could have cared less if anyone thought he was not.


Patria    Posted 06-17-2004 at 18:46:48       [Reply]  [No Email]
hmm..I hear you..then again it seems like some people take these forums too seriously. As if some did not have a real life at all..and that's sad.:-)


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